Carcinogenic Liver Fluke and Others Contaminated in Pickled Fish of Northeastern Thailand
نویسندگان
چکیده
Twenty provinces in northeastern Thailand were investigated for fluke metacercariae contamination in pickled fish, or pla-som, during January –June 2016. A total of 129 pickled fish shops were randomly chosen. Samples were digested with acid-pepsin and those found to be infected with metacercariae were fed to hamsters to test for metacercariae infectivity. The results demonstrated that only 20.2% of the pla-som samples were infected with fluke metacercariae (mc), at various levels (1 to 268 mc/kg). All recovered fluke metacercariae were inactive, degenerated and could not develop to adults in the animal model. In conclusion, the fluke mc infection status in pla-som was correlated with the prevalence of fluke infection in this region known for high O.viverrini and cholangiocarcinoma development. Clearly, systematic control of the fluke life cycle is needed. Whether pickling is an effective preventive measure needs further assessment.
منابع مشابه
Review Genes and Cholangiocarcinoma
Cholangiocarcinoma (CCA) is a major public health problem in the northeastern part of Thailand where the prevalence of this cancer is highest in the world. It is a slow growing tumor but highly metastatic with a poor prognosis. The traditional habit of eating raw fish, repeated exposure to liver fluke and consumption of nitrosamine-contaminated food are major risk factors. Understanding of carc...
متن کاملRaw Fish Consuming Behavior Related to Liver Fluke Infection among Populations at Risk of Cholangiocarcinoma in Nakhon Ratchasima Province, Thailand.
Opisthorchiasis is a health problem in rural communities of Thailand, particularly in the northeast and north regions. Therefore, this study aimed to investigate raw fish consuming behavior related to liver fluke infection among the population at risk for opisthorchiasis and cholangiocarcinoma (CCA). A cross-sectional descriptive study was conducted in Meuang Yang district, Nakhon Ratchasima pr...
متن کاملCarcinogenic human liver fluke: current status of Opisthorchis viverrini metacercariae in Nakhon Ratchasima, Thailand.
BACKGROUND Opisthorchis viverrini infection is a serious public-health problem in Southeast Asia. It is associated with a number of hepatobiliary diseases and the evidence strongly indicates that liver fluke infection is the etiology of cholangiocarcinoma. OBJECTIVES This study aimed to investigate Opisthorchis viverrini metacercarial infection in cyprinoid fish collected from 32 districts of...
متن کاملCholangiocarcinoma Associated with Liver Fluke Infection in an Iranian Patient
Biliary liver flukes are common parasites in some regions of the world where consumption of raw fresh-water fish is a cultural practice. Clonorchis sinensis and Opisthorchis species are the major biliary liver flukes associated with human disease. Some of these parasites are highly associated with cholan...
متن کاملPesticides, fresh water fish, liver flukes and nitrosamines: A story of cholangiocarcinoma development in Thailand.
Cholangiocarcinoma is a common hepatobiliary carcinoma in Thailand. It is believed that both chronic exposure to liver fluke infestation and nitrosamine exposure are the two main underlying factors leading to the carcinogenesis. Here, the author further extrapolates and proposes a new hypothesis based on the environmental ecological data that the stimulation of fresh water fish by contaminated ...
متن کامل